First-Passage Time to Clear the Way for Receptor-Ligand Binding in a Crowded Environment
First-Passage Time to Clear the Way for Receptor-Ligand Binding in a Crowded Environment
Certain biological reactions, such as receptor-ligand binding at cell-cell interfaces and macromolecules binding to biopolymers, require many smaller molecules crowding a reaction site to be cleared. Examples include the T cell interface, a key player in immunological information processing. Diffusion sets a limit for such cavitation to occur spontaneously, thereby …