Using family members to augment genetic case–control studies of a life‐threatening disease
Using family members to augment genetic case–control studies of a life‐threatening disease
Survival bias is difficult to detect and adjust for in case–control genetic association studies but can invalidate findings when only surviving cases are studied and survival is associated with the genetic variants under study. Here, we propose a design where one genotypes genetically informative family members (such as offspring, parents, …