Requirements for efficient cell-type proportioning: regulatory timescales, stochasticity and lateral inhibition
Requirements for efficient cell-type proportioning: regulatory timescales, stochasticity and lateral inhibition
The proper functioning of multicellular organisms requires the robust establishment of precise proportions between distinct cell-types. This developmental differentiation process typically involves intracellular regulatory and stochastic mechanisms to generate cell-fate diversity as well as intercellular mechanisms to coordinate cell-fate decisions at tissue level. We thus surmise that key insights about …