Change point analysis of histone modifications reveals epigenetic blocks linking to physical domains
Change point analysis of histone modifications reveals epigenetic blocks linking to physical domains
Histone modification is a vital epigenetic mechanism for transcriptional control in eukaryotes. High-throughput techniques have enabled whole-genome analysis of histone modifications in recent years. However, most studies assume one combination of histone modification invariantly translates to one transcriptional output regardless of local chromatin environment. In this study we hypothesize that, …