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Prentice's Approach and the Meta‐Analytic Paradigm: A Reflection on the Role of Statistics in the Evaluation of Surrogate Endpoints
Summary We put a perspective on the strengths and limitations of statistical methods for the evaluation of surrogate endpoints. Whereas using several trials overcomes some of the limitations of a single‐trial framework ( Prentice, 1989 , Statistics in Medicine 8, 431–440), arguably the evaluation of surrogate endpoints can never be …