Design principle of gene expression used by human stem cells: implication for pluripotency
Design principle of gene expression used by human stem cells: implication for pluripotency
Human embryonic stem cells (ESC) are undifferentiated and are endowed with the capacities of self-renewal and pluripotential differentiation. Adult stem cells renew their own tissue, but whether they can transdifferentiate to other tissues is still controversial. To understand the genetic program that underlies the pluripotency of stem cells, we compared …