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A Hybrid Model for Combining Case–Control and Cohort Studies in Systematic Reviews of Diagnostic Tests

A Hybrid Model for Combining Case–Control and Cohort Studies in Systematic Reviews of Diagnostic Tests

Systematic reviews of diagnostic tests often involve a mixture of case-control and cohort studies. The standard methods for evaluating diagnostic accuracy only focus on sensitivity and specificity and ignore the information on disease prevalence contained in cohort studies. Consequently, such methods cannot provide estimates of measures related to disease prevalence, …