Binding properties and evolution of homodimers in protein-protein interaction networks
Binding properties and evolution of homodimers in protein-protein interaction networks
We demonstrate that protein-protein interaction networks in several eukaryotic organisms contain significantly more self-interacting proteins than expected if such homodimers randomly appeared in the course of the evolution. We also show that on average homodimers have twice as many interaction partners than non-self-interacting proteins. More specifically, the likelihood of a …