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Inferring Heterogeneous Evolutionary Processes Through Time: from Sequence Substitution to Phylogeography

Inferring Heterogeneous Evolutionary Processes Through Time: from Sequence Substitution to Phylogeography

Molecular phylogenetic and phylogeographic reconstructions generally assume time-homogeneous substitution processes. Motivated by computational convenience, this assumption sacrifices biological realism and offers little opportunity to uncover the temporal dynamics in evolutionary histories. Here, we propose an evolutionary approach that explicitly relaxes the time-homogeneity assumption by allowing the specification of different infinitesimal …