Cancer stem cells: small subpopulation or evolving fraction?
Cancer stem cells: small subpopulation or evolving fraction?
Central to the debate about cancer stem cells in solid tumors is the proportion of cells that can initiate, propagate, and re-initiate tumors. An initially assumed minor subpopulation is confronted with recent data suggesting as many as 30% of primary tumor cells have stem cell characteristics. This review discusses quantitative …