A comparison of Bayesian adaptive randomization and multi‐stage designs for multi‐arm clinical trials
A comparison of Bayesian adaptive randomization and multi‐stage designs for multi‐arm clinical trials
When several experimental treatments are available for testing, multi-arm trials provide gains in efficiency over separate trials. Including interim analyses allows the investigator to effectively use the data gathered during the trial. Bayesian adaptive randomization (AR) and multi-arm multi-stage (MAMS) designs are two distinct methods that use patient outcomes to …