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Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study
<b>Objective</b> To examine whether the association of inadequate or unclear allocation concealment and lack of blinding with biased estimates of intervention effects varies with the nature of the intervention or outcome. <b>Design</b> Combined analysis of data from three meta-epidemiological studies based on collections of meta-analyses. <b>Data sources</b> 146 meta-analyses including …