Antiviral Resistance and the Control of Pandemic Influenza
Antiviral Resistance and the Control of Pandemic Influenza
Background The response to the next influenza pandemic will likely include extensive use of antiviral drugs (mainly oseltamivir), combined with other transmission-reducing measures. Animal and in vitro studies suggest that some strains of influenza may become resistant to oseltamivir while maintaining infectiousness (fitness). Use of antiviral agents on the scale …