Risk of bias: a simulation study of power to detect study-level moderator effects in meta-analysis
Risk of bias: a simulation study of power to detect study-level moderator effects in meta-analysis
There are both theoretical and empirical reasons to believe that design and execution factors are associated with bias in controlled trials. Statistically significant moderator effects, such as the effect of trial quality on treatment effect sizes, are rarely detected in individual meta-analyses, and evidence from meta-epidemiological datasets is inconsistent. The …