Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators
Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators
Mendelian randomization (MR) is a method for estimating the causal relationship between an exposure and an outcome using a genetic factor as an instrumental variable (IV) for the exposure. In the traditional MR setting, data on the IV, exposure, and outcome are available for all participants. However, obtaining complete exposure …