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Exploiting Gene‐Environment Independence for Analysis of Case–Control Studies: An Empirical Bayes‐Type Shrinkage Estimator to Trade‐Off between Bias and Efficiency
Summary Standard prospective logistic regression analysis of case–control data often leads to very imprecise estimates of gene‐environment interactions due to small numbers of cases or controls in cells of crossing genotype and exposure. In contrast, under the assumption of gene‐environment independence, modern “retrospective” methods, including the “case‐only” approach, can estimate …