A Bayesian response‐adaptive covariate‐balanced randomization design with application to a leukemia clinical trial
A Bayesian response‐adaptive covariate‐balanced randomization design with application to a leukemia clinical trial
Abstract We propose a Bayesian response‐adaptive covariate‐balanced (RC) randomization design for multiple‐arm comparative clinical trials. The goal of the design is to skew the allocation probability to more efficacious treatment arms, while also balancing the distribution of the covariates across the arms. In particular, we first propose a new covariate‐adaptive …