Intratumor Heterogeneity in Evolutionary Models of Tumor Progression
Intratumor Heterogeneity in Evolutionary Models of Tumor Progression
Abstract With rare exceptions, human tumors arise from single cells that have accumulated the necessary number and types of heritable alterations. Each such cell leads to dysregulated growth and eventually the formation of a tumor. Despite their monoclonal origin, at the time of diagnosis most tumors show a striking amount …