Mendelian Randomization: New Applications in the Coming Age of Hypothesis-Free Causality
Mendelian Randomization: New Applications in the Coming Age of Hypothesis-Free Causality
Mendelian randomization (MR) is an approach that uses genetic variants associated with a modifiable exposure or biological intermediate to estimate the causal relationship between these variables and a medically relevant outcome. Although it was initially developed to examine the relationship between modifiable exposures/biomarkers and disease, its use has expanded to …