Response‐adaptive decision‐theoretic trial design: operating characteristics and ethics
Response‐adaptive decision‐theoretic trial design: operating characteristics and ethics
Adaptive randomization is used in clinical trials to increase statistical efficiency. In addition, some clinicians and researchers believe that using adaptive randomization leads necessarily to more ethical treatment of subjects in a trial. We develop Bayesian, decision-theoretic, clinical trial designs with response-adaptive randomization and a primary goal of estimating treatment …