Generalizing Evidence From Randomized Clinical Trials to Target Populations: The ACTG 320 Trial
Generalizing Evidence From Randomized Clinical Trials to Target Populations: The ACTG 320 Trial
Properly planned and conducted randomized clinical trials remain susceptible to a lack of external validity.The authors illustrate a model-based method to standardize observed trial results to a specified target population using a seminal human immunodeficiency virus (HIV) treatment trial, and they provide Monte Carlo simulation evidence supporting the method.The example …