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Joint frailty models for recurring events and death using maximum penalized likelihood estimation: application on cancer events

Joint frailty models for recurring events and death using maximum penalized likelihood estimation: application on cancer events

The observation of repeated events for subjects in cohort studies could be terminated by loss to follow-up, end of study, or a major failure event such as death. In this context, the major failure event could be correlated with recurrent events, and the usual assumption of noninformative censoring of the …