The Influence of Bioreactor Geometry and the Mechanical Environment on Engineered Tissues
The Influence of Bioreactor Geometry and the Mechanical Environment on Engineered Tissues
A three phase model for the growth of a tissue construct within a perfusion bioreactor is examined. The cell population (and attendant extracellular matrix), culture medium, and porous scaffold are treated as distinct phases. The bioreactor system is represented by a two-dimensional channel containing a cell-seeded rigid porous scaffold (tissue …