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Boosting method for nonlinear transformation models with censored survival data

Boosting method for nonlinear transformation models with censored survival data

We propose a general class of nonlinear transformation models for analyzing censored survival data, of which the nonlinear proportional hazards and proportional odds models are special cases. A cubic smoothing spline-based component-wise boosting algorithm is derived to estimate covariate effects nonparametrically using the gradient of the marginal likelihood, that is …