Testing Hardy-Weinberg equilibrium with a simple root-mean-square statistic
Testing Hardy-Weinberg equilibrium with a simple root-mean-square statistic
We provide evidence that, in certain circumstances, a root-mean-square test of goodness of fit can be significantly more powerful than state-of-the-art tests in detecting deviations from Hardy–Weinberg equilibrium. Unlike Pearson's |$\chi ^2$| test, the log-likelihood-ratio test, and Fisher's exact test, which are sensitive to relative discrepancies between genotypic frequencies, the …