Necrosis and Apoptosis: Distinct Cell Loss Mechanisms in a Mathematical Model of Avascular Tumour Growth
Necrosis and Apoptosis: Distinct Cell Loss Mechanisms in a Mathematical Model of Avascular Tumour Growth
During the initial avascular phase of solid tumour growth, it is the balance between cell proliferation and cell loss that determines whether the tumour colony expands or regresses. Experimentalists have identified two distinct mechanisms that contribute to cell loss. These are apoptosis and nicrosis. Cell loss due to apoptosis may …