A multi-stage drop-the-losers design for multi-arm clinical trials
A multi-stage drop-the-losers design for multi-arm clinical trials
Multi-arm multi-stage trials can improve the efficiency of the drug development process when multiple new treatments are available for testing. A group-sequential approach can be used in order to design multi-arm multi-stage trials, using an extension to Dunnett's multiple-testing procedure. The actual sample size used in such a trial is …