Response‐adaptive randomization for clinical trials with adjustment for covariate imbalance
Response‐adaptive randomization for clinical trials with adjustment for covariate imbalance
Abstract In clinical trials with a small sample size, the characteristics (covariates) of patients assigned to different treatment arms may not be well balanced. This may lead to an inflated type I error rate. This problem can be more severe in trials that use response‐adaptive randomization rather than equal randomization …