A likelihood ratio test of population Hardy‐Weinberg equilibrium for case‐control studies
A likelihood ratio test of population Hardy‐Weinberg equilibrium for case‐control studies
Abstract Testing Hardy‐Weinberg equilibrium (HWE) in the control group is commonly used to detect genotyping errors in genetic association studies. We propose a likelihood ratio test for testing HWE in the study population using both case and control samples. This test incorporates underlying association models. Another feature is that, when …