Discussion on “Second-Guessing Clinical Trial Designs” by Jonathan J. Shuster and Myron N. Chang
Discussion on “Second-Guessing Clinical Trial Designs” by Jonathan J. Shuster and Myron N. Chang
Abstract Professors Shuster and Chang provided some optimal group sequential designs, where the optimization is done by a “grid search” method, before the trial begins. In this discussion, we suggest possible modification of the design where the design to be carried out in a stage-wise fashion, and the design for …