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From Signal Transduction to Spatial Pattern Formation in<i>E. coli</i>: A Paradigm for Multiscale Modeling in Biology

From Signal Transduction to Spatial Pattern Formation in<i>E. coli</i>: A Paradigm for Multiscale Modeling in Biology

The collective behavior of bacterial populations provides an example of how cell-level decision making translates into population-level behavior and illustrates clearly the difficult multiscale mathematical problem of incorporating individual-level behavior into population-level models. Here we focus on the flagellated bacterium E. coli, for which a great deal is known about …