A Bayesian Dose-finding Design for Drug Combination Trials with Delayed Toxicities
A Bayesian Dose-finding Design for Drug Combination Trials with Delayed Toxicities
We propose a Bayesian adaptive dose-finding design for drug combination trials with delayed toxicity. We model the dose-toxicity relationship using the Finney model, a model widely used in drug-drug interaction studies. The intuitive interpretations of the Finney model facilitate incorporating the available prior dose-toxicity information from single-agent trials into combination …