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Comparison of dynamic block randomization and minimization in randomized trials: a simulation study

Comparison of dynamic block randomization and minimization in randomized trials: a simulation study

Background Minimizing the imbalance of key baseline covariates between treatments is known to be very important to the precision of the estimate of treatment effect in clinical research. Dynamic randomization allocation techniques have been used to achieve balance across multiple baseline characteristics. However, empirical data are limited on how these …