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A Joint Frailty Model for Survival and Gap Times Between Recurrent Events

A Joint Frailty Model for Survival and Gap Times Between Recurrent Events

Therapy for patients with a recurrent disease focuses on delaying disease recurrence and prolonging survival. A common analysis approach for such data is to estimate the distribution of disease-free survival, that is, the time to the first disease recurrence or death, whichever happens first. However, treating death similarly as disease …