Score Test for Familial Aggregation in Probands Studies: Application to Alzheimer's Disease
Score Test for Familial Aggregation in Probands Studies: Application to Alzheimer's Disease
When studying familial aggregation of a disease, the following two-stage design is often used: first select index subjects (cases and controls); then record data on their relatives. The likelihood corresponding to this design is derived and a score test of homogeneity is proposed for testing the hypothesis of no-aggregation. This …