Evaluating surrogate endpoints, prognostic markers, and predictive markers: Some simple themes
Evaluating surrogate endpoints, prognostic markers, and predictive markers: Some simple themes
A surrogate endpoint is an endpoint observed earlier than the true endpoint (a health outcome) that is used to draw conclusions about the effect of treatment on the unobserved true endpoint. A prognostic marker is a marker for predicting the risk of an event given a control treatment; it informs …