Crypt dynamics and colorectal cancer: advances in mathematical modelling
Crypt dynamics and colorectal cancer: advances in mathematical modelling
Abstract. Mathematical modelling forms a key component of systems biology, offering insights that complement and stimulate experimental studies. In this review, we illustrate the role of theoretical models in elucidating the mechanisms involved in normal intestinal crypt dynamics and colorectal cancer. We discuss a range of modelling approaches, including models …