Sample size calculation for the proportional hazards cure model
Sample size calculation for the proportional hazards cure model
In clinical trials with timeātoāevent endpoints, it is not uncommon to see a significant proportion of patients being cured (or longāterm survivors), such as trials for the nonāHodgkins lymphoma disease. The popularly used sample size formula derived under the proportional hazards (PH) model may not be proper to design a ā¦