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A mathematical model of the impact of infused targeted cytotoxic agents on brain tumours: implications for detection, design and delivery
Abstract. Motivated by the recent development of highly specific agents for brain tumours, we develop a mathematical model of the spatioātemporal dynamics of a brain tumour that receives an infusion of a highly specific cytotoxic agent (e.g. ILā4āPE, a cytotoxin comprised of ILā4 and a mutated form of Pseudomonas exotoxin). ā¦