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The Timing and Targeting of Treatment in Influenza Pandemics Influences the Emergence of Resistance in Structured Populations
Antiviral resistance in influenza is rampant and has the possibility of causing major morbidity and mortality. Previous models have identified treatment regimes to minimize total infections and keep resistance low. However, the bulk of these studies have ignored stochasticity and heterogeneous contact structures. Here we develop a network model of …