Identifying main effects and epistatic interactions from large-scale SNP data via adaptive group Lasso
Identifying main effects and epistatic interactions from large-scale SNP data via adaptive group Lasso
Single nucleotide polymorphism (SNP) based association studies aim at identifying SNPs associated with phenotypes, for example, complex diseases. The associated SNPs may influence the disease risk individually (main effects) or behave jointly (epistatic interactions). For the analysis of high throughput data, the main difficulty is that the number of SNPs …