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Correlation-Adjusted Estimation of Sensitivity and Specificity of Two Diagnostic Tests

Correlation-Adjusted Estimation of Sensitivity and Specificity of Two Diagnostic Tests

Summary Models for multiple-test screening data generally require the assumption that the tests are independent conditional on disease state. This assumption may be unreasonable, especially when the biological basis of the tests is the same. We propose a model that allows for correlation between two diagnostic test results. Since models …