Youden Index and Optimal Cut‐Point Estimated from Observations Affected by a Lower Limit of Detection
Youden Index and Optimal Cut‐Point Estimated from Observations Affected by a Lower Limit of Detection
The receiver operating characteristic (ROC) curve is used to evaluate a biomarker's ability for classifying disease status. The Youden Index (J), the maximum potential effectiveness of a biomarker, is a common summary measure of the ROC curve. In biomarker development, levels may be unquantifiable below a limit of detection (LOD) …