A New ‘Biased Coin Design’ for the Sequential Allocation of Two Treatments
A New ‘Biased Coin Design’ for the Sequential Allocation of Two Treatments
Summary Efron’s biased coin design is a well-known randomization technique that helps to neutralize selection bias in sequential clinical trials for comparing treatments, while keeping the experiment fairly balanced. Extensions of the biased coin design have been proposed by several researchers who have focused mainly on the large sample properties …