Up-and-Down Designs for Selecting the Dose with Maximum Success Probability
Up-and-Down Designs for Selecting the Dose with Maximum Success Probability
Abstract Assume that the probability of success is unimodal as a function of dose, such as may be the case when too much of a drug is toxic and too little is ineffective. We characterize a class of up-and-down designs, that is, treatment allocation methodologies, for identifying the dose that …