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A multicriteria framework with voxel‐dependent parameters for radiotherapy treatment plan optimization

A multicriteria framework with voxel‐dependent parameters for radiotherapy treatment plan optimization

Purpose: To establish a new mathematical framework for radiotherapy treatment optimization with voxel‐dependent optimization parameters. Methods: In the treatment plan optimization problem for radiotherapy, a clinically acceptable plan is usually generated by an optimization process with weighting factors or reference doses adjusted for a set of the objective functions associated …