Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials
Asymptotic properties of doubly adaptive biased coin designs for multitreatment clinical trials
A general doubly adaptive biased coin design is proposed for the allocation of subjects to K treatments in a clinical trial. This design follows the same spirit as Efron's biased coin design and applies to the cases where the desired allocation proportions are unknown, but estimated sequentially. Strong consistency, a …