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Spatial Clustering of Array CGH Features in Combination with Hierarchical Multiple Testing

Spatial Clustering of Array CGH Features in Combination with Hierarchical Multiple Testing

We propose a new approach for clustering DNA features using array CGH data from multiple tumor samples. We distinguish data-collapsing: joining contiguous DNA clones or probes with extremely similar data into regions, from clustering: joining contiguous, correlated regions based on a maximum likelihood principle. The model-based clustering algorithm accounts for …