Splitting Probabilities as a Test of Reaction Coordinate Choice in Single-Molecule Experiments
Splitting Probabilities as a Test of Reaction Coordinate Choice in Single-Molecule Experiments
To explain the observed dynamics in equilibrium single-molecule measurements of biomolecules, the experimental observable is often chosen as a putative reaction coordinate along which kinetic behavior is presumed to be governed by diffusive dynamics. Here, we invoke the splitting probability as a test of the suitability of such a proposed …