The Role of Cell Density and Intratumoral Heterogeneity in Multidrug Resistance
The Role of Cell Density and Intratumoral Heterogeneity in Multidrug Resistance
Abstract Recent data have demonstrated that cancer drug resistance reflects complex biologic factors, including tumor heterogeneity, varying growth, differentiation, apoptosis pathways, and cell density. As a result, there is a need to find new ways to incorporate these complexities in the mathematical modeling of multidrug resistance. Here, we derive a …